End-to-End Precision Fermentation Services for Every Stage of Commercial Scale-Up and Process Development
iPROOF is a demonstration-scale biomanufacturing facility in Decatur, IL, offering end-to-end bioproduction services, bioprocess development, and commercial scale-up support for companies advancing the bioeconomy. Through our industry partnerships and deep expertise in technology and commercial readiness, we connect partners to infrastructure, expertise, and a path to commercialization.
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Fermentation Capacity – Level of Excellence
Lab
10 – 150 L
Pilot
2 X 1,500 L
(STRs | 200-300 mmol/L/hr OUR)
Demonstration
2 X 10,000 L
(STRs | 150-300 mmol/L/hr OUR)
Run Modes
✔ Aerobic
✔ Batch
✔ Fed-Batch
✔ Continuous
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Downstream Unit Operations
✔ Disk stack centrifuge
✔ Ceramic microfiltration
✔ Spiral microfiltration, ultrafiltration & nanofiltration
✔ Evaporator
✔ Spray Dryer
✔ HTST
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What We Offer
Our highly technical and trained staff and network experts are here to guide you. With nearly 50 years in commercial industrial fermentation expertise, iPROOF is well positioned to support your innovations as they become commercial realities.
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Downstream Process Optimization
Data-driven improvements at every unit operation
Bioprocess Development
From critical process parameter definition to scale-ready documentation
Fermentation Optimization
Data-driven titer, rate, and yield improvement at every stage
Real-Time Process Monitoring and PAT
Automated tracking of pH, dissolved oxygen, off-gas, and more
Upstream Processing
Seed train development with seamless transitions from 10 L to 10,000 L working volume
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Precision Fermentation Services
Full-scale fermentation support for microbial, yeast (including Pichia), fungal and algal (non-photobioreactor) systems
Downstream Process Development
Modular recovery and purification from inactivation through liquid formulation or spray drying
Co-Location and Campus Access
On-site partnership opportunities within our broader strategic partnerships via innovative wet mill campuses (Decatur, Lafayette, Loudon)
Industry & Service Provider Connections
Connecting clients with specialized partners and external service providers across the broader biomanufacturing ecosystem
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Why iPROOF
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World-Class Manufacturing Expertise
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Accelerated Tech Transfer
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Direct Scale Pathway
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iPROOF offers the ability to rapidly advance towards commercialization enabled by integrated wet mill feedstocks and established infrastructure.
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